Self Employed, Selling Rental Property C.G. Question?

I am self employed and have some rental properties because of Medical bills, we need to sell one of the properties and will Probably make $20-25 K out of the sale. Is CG tax, taxed no matter what kind of other losses you show from other businesses or properties. Or is it all lumped together so if I had a 10 k loss in business and 20 K gain in sale of property, I would be taxed on 10k or Do I pay taxes on just the house sale profit no matter what. Thanks Dave